INS and cardiovascular disorder: Before SOTA was discovered, oral hypoglycemic drugs always led to increased weight, thus increasing the risk of cardiovascular disease.[18] A study found that after single administration of 300 mg of SOTA, 44 g of glucose was excreted in the urine in 24 hours.[19] Sugar excreted through the urine can reduce a patient's required insulin dose and; therefore, reduce the patient's dependence on insulin.