Our findings may be extended to patients developing drug-induced hyponatremia with an SIADH-like syndrome (excessive secretion of ADH or excessive responsivity of distal convoluted and collecting tubule to ADH [increased receptor expression or enhanced ligand binding effector coupling]) In patients requiring continued treatment with TMP/SMX (those with a highly pathogenic multidrug resistance organism), intravenous saline hydration may effectively ameliorate or reverse the hyponatremia sans discontinuation of the drug. This evidence concerns the gene AVP and Hyponatremia.