TSC2 and Renal insufficiency: These changes can result in complications such as learning difficulties, epilepsy, behavioral problems, and renal failure.[4] The incidence of TSC is 1/6000 to 1/1000 in neonates and 1/8000 in adults.[5] TSC is caused by a mutation of the tuberous sclerosis 1 (TSC1) or tuberous sclerosis 2 (TSC2) gene.