HNF1B and neurodevelopmental disorder: In approximately 50% of MODY 5 patients, the disease is caused by whole HNF1B deletions, where 50% of the deletions are de novo.[16–18] Compared to patients with HNF1B intragenic mutations, those with HNF1B deletions have better renal prognoses,[18–20] but are more likely to exhibit neurodevelopmental disorders.[19,21] HNF1B is located on chromosome 17q12, which also contains 14 other genes.