This mutation is predicted to delete that domain.[15] While NCOA4, PTEN, and EPHA3 mutations have not been reported in SMZL, the COSMIC (catalogue of somatic mutations in cancer) database (https://cancer.sanger.ac.uk/cosmic) shows that c.689G > A mutation of PTEN occurs in glioma, and c.935G > A mutation of EPHA3 occurs in colon, liver, and prostate cancers. This evidence concerns the gene PTEN and central nervous system cancer.