INS and obesity due to melanocortin 4 receptor deficiency: Studies on the effect of supplementation in adolescents and young adults are scarce; however, the favorable effect of supplementation in the serum levels of 25 (OH) D in school-age children with VDD and the reduction in blood pressure, the concentration of fasting glucose, and improvements in sensitivity to insulin in children with overweight and obesity is widely known.[14,15] Notwithstanding this, more clinical trials are required to confirm these findings.