On univariate analysis, age (Hazard ratio [HR] = 3.846, P = .006), tumor size (HR = 1.602, P = .001), higher pathological TNM stage (HR = 4.433, P < .001), RCRG grade (HR = 2.552, P = .005), post-NCRT CEA level (HR = 3.725, P = .008), post-NCRT CA19-9 level (HR = 3.958, P = .031), vascular invasion (HR = 0.200, P = .033), and DRM involvement (HR = 0.022, P < .001) were independently associated with local recurrence in LARC patients following NCRT. This evidence concerns the gene CEACAM5 and neoplasm.