NFKB1 and gastrointestinal disease: 2018) and inducing the activation of the NF-κB signalling pathway (Rozza et al. 2014). Studies have shown that the release and expression of IL-1β and IL-6 play an important role in gastrointestinal diseases such as gastric ulcer (Plebani et al. 1995), gastric cancer (Kabir et al. 1995) and colitis (Yamamoto et al. 2000; Wang et al. 2014).