TNF and type 2 diabetes mellitus: The inflammatory cytokine TNF has been shown to be involved in many biological processes including fever, apoptosis, and infection-induced cachexia [16], as well as in inflammation-associated diseases, for example rheumatoid arthritis [35], acquired generalized lipodystrophy and combined Crohn’s disease [36], Crohn's disease [37], and type 2 diabetes [38].