MALT1 and Autoimmunity: Interestingly, while mice with MALT1-deficient Tregs and mice with enzymatically-dead MALT1 in Tregs both developed autoimmune-like wasting disease, only full MALT1-KO in Tregs reduced splenic Treg frequencies and increased IFNg/IL17 production in conventional CD4 T cells [40].