A recent study investigating the mode of action of glatiramer acetate (Copaxone), a peptide-based drug licensed in the late 1990s, used to treat patients with the relapsing-remitting form of multiple sclerosis that ameliorates autoimmunity, identified LILRB2 and LILRB3 as potential ligands (58). This evidence concerns the gene LILRB3 and multiple sclerosis.