Kidney injury models such as 5/6 nephrectomy (38), adriamycin nephropathy (39), the MWF spontaneous albuminuria rat model (18), STZ diabetic nephropathy (40), aldosterone treatment (19), and the Zucker fatty rat obese model (41) are characterized by glomerular endothelial glycocalyx shedding causing albumin leakage. The gene discussed is ALB; the disease is diabetic kidney disease.