Indeed, it has been proven that BCM triggers a prominent response of TGF-β signaling pathways by modulating the expression of adrenomedulin (ADM), pentraxin 3 (PTX3), BTB/POZ domain-containing protein 11 (BTBD11), interleukin-11 (IL-11), NADPH oxidase 4 (NOX4), and proteoglycan 4 (PRG4), all known downstream regulators of the TGF-β signaling cascade [8]. This evidence concerns the gene NOX4 and blue cone monochromacy.