ATXN2 and amyotrophic lateral sclerosis: On the other hand, there are severe infantile cases with expansions between 50-70 repeats, sometimes is related with interruption CTG or CAA as occurs in adults with SCA2 and amyotrophic lateral sclerosis, which also leads to instability of ATXN2 mRNA (Choudhry et al., 2001; Antenora et al., 2017), and meiotic instability a general feature of SCA2 without a familial history (Babovic et al., 1998; Mao et al., 2002; Moretti et al., 2004; Dirik et al., 2007; Abdel and Zaki, 2008; Paciorkowski et al., 2011; Di Fabio et al., 2012; Vinther-Jensen et al., 2013; Singh et al., 2014).