ATXN2 and Insulin resistance: This might support a previously suggested relationship between the ataxin-2 gene and body weight and insulin resistance, which is modulated by ataxin-2 by the pathway of insulin by GRB2 and SRC (Flores-Alvarado et al., 2016; Guzmán-López et al., 2018; Ramirez-Garcia et al., 2019).