HPSE and endometrial carcinoma: In EC, previous studies showed higher HPSE expression in endometrial carcinoma of grade 2 + 3, advanced FIGO stage and carcinoma with deep myometrial invasion, positive lymph node, lymphvascular space involvement (Canaani et al., 2008; Inamine et al., 2008; Hasengaowa et al., 2006).