After the cloning of a single human heparanase cDNA in 1999 and the presence of derivative genetic tools, researchers began to accept the notion that this enzyme activity toward HS affects various biological activities including remodeling of the ECM barrier and regulating of HS‐linked cytokines and growth factors, contributing to tumor angiogenesis and metastasis (Barash et al., 2010; Iozzo & Sanderson, 2011; Sanderson, Yang, Suva, & Kelly, 2004; Vlodavsky & Friedmann, 2001). Here, HPSE is linked to neoplasm.