Previous studies showed high HPSE expression in nearly all human carcinomas examined including renal (Mikami et al., 2008), thyroid (Matos et al., 2015), hepatocellular (Chen, Dang, Luo, Feng, & Tang, 2008), lung (Fernandes et al., 2014), breast (Gawthorpe et al., 2014), ovarian (Davidson et al., 2007), and endometrial cancer (Inamine et al., 2008). Here, HPSE is linked to endometrial cancer.