The preservation of cholinergic interneurons in HD striatum is nonetheless accompanied by diminished expression of such cholinergic neuron markers as ChAT (Aquilonius, Eckernas, & Sundwall, 1975; Ferrante, Beal, et al., 1987; Massouh et al., 2008; Spokes, 1980; Suzuki, Desmond, Albin, & Frey, 2001) and the vesicular acetylcholine transporter (VAChT; Smith et al., 2006). This evidence concerns the gene CHAT and Huntington disease.