First of all, the meta-analysis is based on case–control study, and there may have selection bias; second, the analysis of the relationship between miR-145 and specific clinicopathological characteristics of breast cancer, such as ER, PR, HER-2, lymph node metastasis and tumor size etc., due to the relatively small number of studies included, the results need to be further confirmed. The gene discussed is ERBB2; the disease is breast carcinoma.