We found a significant overrepresentation in the lower 2.5th DoS quantile (i.e. genes under relaxation of selection) in the GNP population for pathways associated with age-related diseases, including gastric cancer, breast cancer, neurodegenerative disease, mTOR signaling and WNT signaling (q-value <0.05, Figure 5b, Supplementary file 1I). This evidence concerns the gene MTOR and breast cancer.