CRK and neurodegenerative disease: The kinase c‐Abl can be activated by multiple stimuli, leading to cytoskeletal reorganization, which is required for cell morphogenesis, mobility, adhesion, and polarity. The activity of c‐Abl plays a critical role in the regulation of apoptosis and has been linked to the pathogenesis of neurodegenerative diseases. To study the activity of c‐Abl, we first constructed the Myc‐CRK plasmid.