Among the interleukin family, secretion of IL‐33 in esophageal epithelial cells has been reported to prompt the occurrence of gastroesophageal reflux diseases and lead to Barrett esophagus;31 IL‐4, IL‐13,32 IL‐1β33 and IL‐6 34 contributed to increased secretion of esophageal mucosa in patients with Barrett's esophagus, and IL‐11 contributed to esophageal squamous cell carcinoma progression and its aggressiveness.35 Here, IL4 is linked to esophageal squamous cell carcinoma.