IL4 and gastroesophageal reflux disease: Among the interleukin family, secretion of IL‐33 in esophageal epithelial cells has been reported to prompt the occurrence of gastroesophageal reflux diseases and lead to Barrett esophagus;31 IL‐4, IL‐13,32 IL‐1β33 and IL‐6 34 contributed to increased secretion of esophageal mucosa in patients with Barrett's esophagus, and IL‐11 contributed to esophageal squamous cell carcinoma progression and its aggressiveness.35