CD8A and Granuloma: Given that numerous small and large LNs were involved in inducing antitumor immunity, this dilemma may imply that 4-1BB triggering enhances antitumor CD8+ T cell responses in multiple LNs, including major TDLNs such as inguinal LNs and that every LN may differ in the level of granuloma development and impairment of CD8+ T cell proliferation.