High expression of DKC1 protein whether in the nucleus and/or nucleoli was associated with aggressive features of BC including higher tumour grade (p < 0.0001), larger tumour size (p = 0.04 only with nucleolar expression), higher mitotic scores (p < 0.0001), increased nuclear pleomorphism (p < 0.0001), higher scores of nucleolar prominence (p < 0.001), poor NPI (p < 0.0001) and the invasive ductal no special histological type (NST) (p < 0.0001), Table 1. The gene discussed is DKC1; the disease is neoplasm.