DKC1 and neoplasm: The multivariate Cox-proportional models, including other prognostic covariates such as tumour size, grade and nodal stage, showed that DKC1 nuclear, combinatorial protein expression and DKC1 mRNA in the METABRIC dataset were independent predictors for poor prognosis in whole cases (p = 0.001, HR 2.037, 95% CI = 1.373–3.023, p = 0.003, HR 2.746, 95% CI = 1.484–5.083 and p = 0.006, HR 1.316, 95% CI = 1.097–1.579) as shown in Table 3 and Supplementary Table 5.