The three proteins are interdependent with each other for stability and also regulate constancy of the bound RNAs.57GAR1 binds only to DKC1 and is needed for a proper functioning of the H/ACA RNPs, but its absence does not reduce the stability of the rRNA.58 These findings confirmed the significant positive correlation between H/ACA ribonucleoproteins and DKC1 in BC.43 Alterations in DKC1 expression will potentially disrupt the biogenesis of H/ACA pathway and consequently affect ribosome synthesis and impair cell proliferation. This evidence concerns the gene DKC1 and breast cancer.