The antioxidants had barely any antagonizing effect on the proteasome inhibition of BOZ, except for one combination, where enlargement in the percentage of the chymotrypsin-like protease activity of the proteasome could be monitored following 100 μg/mL ALA + 20 ng/mL BOZ co-treatment in the melanoma cells (Fig. 4A). This evidence concerns the gene CTRL and melanoma.