As shown in Fig. 1E dose-escalated BOZ treatment induced remarkable p53-activation (phosphorylation of p53) even at lower concentrations on melanoma cell line compared to the control group (RFI = BOZ treated cells p53 MFI/control cells p53 MFI; RFI: ratio of the mean fluorescence intensity; MFI: mean fluorescence intensity). The gene discussed is TP53; the disease is melanoma.