Long-term serotonin reuptake inhibition (SRI), which reportedly protects patients with depression from cardiovascular events, has been shown to deplete platelet serotonin stores in mice, while plasma serotonin levels correlated with neutrophil CD11b expression in patients hospitalized with acute coronary syndrome, indicating that inhibition of serotonin uptake may decrease neutrophil activation24. This evidence concerns the gene ITGAM and depressive disorder.