MAGT1 and X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia: Impaired SOCE also can result from a magnesium channel defect due to pathogenic mutations in Magnesium Transporter 1 (MAGT1), which results in X-linked immunodeficiency with magnesium defect, EBV viraemia and neoplasia (XMEN) syndrome57,58.