In the 6-OHDA-induced PD model, pre- or post-treatment with 1,25(OH)2D3 reduced tissue immunopositivity for TNF-α, partially restored tyrosine hydroxylase (TH) immunoreactivity, and prevented the decrease of VDR immunoreactivity in the lesioned striatum [133, 134]. The gene discussed is VDR; the disease is Parkinson disease.