TNF and obesity due to melanocortin 4 receptor deficiency: High amount secretion of inflammatory cytokines from expanded WAT and disproportion in pro-inflammatory and anti-inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein 1 (MCP1), interleukin-6 (IL-6) vs interleukin-10 (IL-10), adiponectin contribute to obesity-related complications [4, 5].