To mimic the up-regulation of TRIM59 expression in TAMs and investigate its role in LC cells growth and metastasis in vivo, we utilized a CD11b promoter-driven macrophages-specific TRIM59 transgenic (TgTRIM59) mouse model, in which the lewis lung carcinoma (LLC) cells were inoculated subcutaneously. This evidence concerns the gene TRIM59 and laryngotracheoesophageal cleft.