In this study, our findings unveil a new sight between tumor cells and macrophages: TRIM59 are directly shuttled from cancer cells via exosomes to macrophages, promoting ABHD5 proteasomal degradation and inducing NLRP3 (NLR family protein containing a pyrin domain 3) inflammasome activation and promoting IL-1β secretion, in turn promoting cancer cells proliferation and invasion. Here, IL1B is linked to neoplasm.