RND2 and central nervous system cancer: To determine whether the levels of RND2 protein were elevated or not in clinical samples, we analysed the expression of RND2 in human glioblastoma samples, including 14 normal brain tissue samples, 31 WHO grade II gliomas, 41 WHO grade III gliomas and 52 glioblastomas, and we found that RND2 expression was significantly higher in gliomas compared with that of normal brain tissues (Fig. 1d, e).