Seven cytokines were identified as infection-specific, showing elevated concentrations in the septic TKR cohort compared to both the aseptic TKR and primary TKA cohorts: IL-1α, IL-1β, IL-6, IL-8, MCP-1, MIP-1α, and MIP-1β (p < 0.05). Here, CXCL8 is linked to infection.