In line with the abovementioned findings, most of the 12 BCSC-related lncRNAs were remarkably associated with ER expression, PR expression and molecular subtypes, which further suggested that the 12 BCSC-related lncRNAs might be involved in the development and progression of breast cancer, and the risk model was also based on the intrinsic properties of breast cancer. Here, ESR1 is linked to breast cancer.