ACHE and early-onset autosomal dominant Alzheimer disease: This couldexplain the disruption of the cell membrane and the loss of cytoplasmic contents (Fig. 1b and c) observed on bacterial cells treated with B. macowanii. Furthermore, the steroidal alkaloids found in the plant have anti-AChE activity or showed prevention of excessive degradation of acetylcholine which is associated with Alzheimer’s disease [39], indicating a multipurpose remedy.