For example, the genes of PSMB9, TAP2, HLA-DPB1, PMM1, and PSMD3. Among these identified 31 convincing genes associated with childhood-onset asthma risk, we found that there existed multiple risk eSNPs associated with transcriptional abundance of a specific gene and disease risk per se simultaneously. The gene discussed is HLA-DPB1; the disease is asthma.