For example, the top-ranked asthma-risk genes with eSNPs were identified to be significant: HLA-DRD3 (FDR = 2.05 × 10− 4), HLA-DQA1 (FDR = 2.05 × 10− 4), HLA-DRB4 (FDR = 2.05 × 10− 4), NOTCH4 (FDR = 2.05 × 10− 4), PSMB9 (FDR = 2.05 × 10− 4), PALZ (FDR = 2.05 × 10− 4), HLA-DRB5 (FDR = 2.05 × 10− 4), HLA-DPB1 (FDR = 2.05 × 10− 4), and HLA-DRB1 (FDR = 2.05 × 10− 4). The gene discussed is HLA-DRB1; the disease is asthma.