A number of 13 genes have been documented to implicate in asthma risk in the GWAS catalog and previous studies; for example, HLA-DQA1, HLA-DRB5, HLA-DRB1, TLR6, and MPHOSPH9. Interestingly, there were 18 genes newly identified to be associated with childhood-onset asthma; e.g., PSMB9, TAP2, PMM1, and ACTR1A. Except for PSMD3, none of these 31 genes obtained any significant or suggestive association signals from MAGMA analysis of GWAS data on Null phenotype (Table 1). The gene discussed is HLA-DRB1; the disease is asthma.