TYR and amyotrophic lateral sclerosis: Notably, with the high precision of eA3G-BE, targeted C-to-T conversions can be induced at target C without generating bystander mutations at Tia1, Dmd, and Tyr-1, thus precisely mimicking the p.P362L missense mutation of human amyotrophic lateral sclerosis (ALS) [18], the p.Q869Stop nonsense mutation of Duchenne muscular dystrophy (DMD) [19], and the p.Q48Stop nonsense mutation of oculocutaneous albinism type 1 (OCA1) [20], respectively (Fig. 3d).