COPB1 and viral infectious disease: Proteins common to all three patients included factors considered to be involved in inhibition of viral infection (such as C1QC, CAMP, DEFB4A, and S100A6), proteins associated with the inflammatory response (IL1Α and IL12B) and cell damage (CASP10, EGF, HSBP1, and DRG2), and proteins with an unknown function in keratitis (PTTG1IP, CALR, CAPS, COPB1, and RAB7A) (Fig. 3b).