TGFB1 and neoplasm: The activated platelets facilitate tumor cell proliferation by secreting a number of angiogenic tumor growth factors, such as thrombopoietin (TPO), platelet factor 4 (PF4), transforming growth factor beta (TGFb), vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) [9,10,11].