Several reports are in in line with our results: if IL-6/gp130/STAT3 pathway is impaired and mice are exposed to AOM-DSS, more severe colitis with more pronounced epithelial damage and ulceration, more prominent infiltration with inflammatory cells can be observed, while tumor load is decreased due to a reduction in size and frequency [26,27,28]. This evidence concerns the gene STAT3 and infectious otitis media.