IL6R and periodontitis: Shaddox et al. (2017) assessed DNA methylation in localized aggressive periodontitis (LAP) for TLR signaling pathway genes, that either result in the upregulation (MYD88, MAP3K7, RIPK2, IL6R) or downregulation (FADD, PPARA, IRAK1BP1) of TLR-mediated inflammation [30].