Shaddox et al. (2017) assessed DNA methylation in localized aggressive periodontitis (LAP) for TLR signaling pathway genes, that either result in the upregulation (MYD88, MAP3K7, RIPK2, IL6R) or downregulation (FADD, PPARA, IRAK1BP1) of TLR-mediated inflammation [30]. This evidence concerns the gene IRAK1BP1 and periodontitis.