CAFs also contribute to tumor progression by remodeling the extracellular matrix through the production of collagen and fibronectin [92]; enhancing cell migration and invasion by degrading matrix enzymes [93]; and increasing cancer cell motility and invasiveness through the generation of pro-invasive and angiogenic molecules like vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6) [94,95]. This evidence concerns the gene VEGFA and neoplasm.