Tumor regression was statistically significantly associated with PD-L1 CPS (Dworak TRG 0–2: 16.0 (median) vs. Dworak TRG 3–4: 29.0 (median), p = 0.02) and PD-L1 IC (Dworak TRG 0–2: 11.0 (median) vs. Dworak TRG 3–4: 18.0 (median), p = 0.02) prior to neoadjuvant CRT, while this was not the case for PD-L1 TPS (Dworak TRG 0–2: 4.0 (median) vs. Dworak TRG 3–4: 3.0 (median), p = 0.24) (Figure 2). This evidence concerns the gene CD274 and neoplasm.