Some key points could be underscored: a) AhR co-ordinates COVID-19 pathophysiology; b) AhR, via mitochondrial metabolism and acetyl-CoA, alters patterned immune responses; c) AhR effects in COVID-19 have overlaps with cancer pathophysiology; d) Racial discrimination stress is proposed to act via the AhR to drive health disparities; e) AhR antagonists may provide prophylaxis and treatment options for COVID-19, cancers, and prevent the biological consequences of racial discrimination stress. Here, AHR is linked to COVID-19.