In accordance with this, we demonstrated that, although the infection with B. abortus induces a mild activation of HBMEC, HMEC-1, and HUVEC, the presence of platelets during the infection enhances its activation state upregulating the expression of ICAM-1 and CD40, thus stressing the amplifying role of platelets on endothelial inflammation [39]. Here, CD40 is linked to infection.