Furthermore, in the tunicates Ciona robusta and Phallusia mammillata, Rimbp forms a triplet (Figure S2) with Rab3Gap1, which in vertebrates is implicated in Warburg and Martsolf syndromes and, like Rimbp proteins, is an effector of Rab3 proteins [39,40,41], and Chmp2 [42]. The gene discussed is CHMP2A; the disease is Cataract - intellectual disability - hypogonadism.