HMGB1 and cancer: Also reinforcing the significance of the interactions detected in our study in relation to clinics, data of gene expression according to Pan-Cancer Analysis of Whole Genomes (PCAWG), and corresponding to 110 tumors of ovarian adenocarcinomas, show that HMGB1, HMGB2 and >90% of their preys detected in this EOC-HMGB-interactome are up-regulated in the comparison between tumor tissue and adjacent non-tumor tissue (Table 3).