HMGB1 and HMGB2 genes were silenced in SKOV-3 and PEO1 EOC cell lines and levels of mRNA from 4 detected interacting partners of HMGB1 or HMGB2 in ovary cancer, COMMD1, MIEN1, NOP53 and ZNF428, were analyzed by qRT-PCR as explained in Materials and Methods. The gene discussed is HMGB2; the disease is ovarian cancer.