Gene expression analysis of a poor survival subgroup of AcCC tumors indicated overexpression of both NR4A3 and MYB. We provide evidence that Myb and NR4A3 proteins directly interact: the ligand binding domain of NR4A3 interacts with the DNA binding domain of Myb, and that association increases the transcriptional activation activity of NR4A3. This evidence concerns the gene NR4A3 and acinar cell carcinoma.