Gene expression analysis of a poor survival subgroup of AcCC tumors indicated overexpression of both NR4A3 and MYB. We provide evidence that Myb and NR4A3 proteins directly interact: the ligand binding domain of NR4A3 interacts with the DNA binding domain of Myb, and that association increases the transcriptional activation activity of NR4A3. The gene discussed is MYB; the disease is acinar cell carcinoma.