In 1467 participants (55.6 ± 9 years, BMI 29.3 ± 6 kg/m2) with normal glucose metabolism (46%), impaired glucose tolerance (22%) and without insulin dependent diabetes mellitus (32%), the estimated energy expenditure (EEE) was assessed by structured interviews, and insulin sensitivity was measured [17]. The gene discussed is INS; the disease is type 1 diabetes mellitus.