ERBB2 and glioblastoma: Indeed, a strict interaction between ErbB2 and TROY was described in glioblastoma cells [58], where Ding and colleagues reported a positive correlation of the expression levels of TROY and EGFRs, which promote each other’s activity: TROY facilitates EGFR activation and delays EGFR internalization, while EGFRs increase TROY-induced NF-κB activation.