Investigating coefficients of correlation between the indices and selected parameters, we found that in patients with septic shock there were statistically significant associations between: PLR and PCT (R = −0.284, p = 0.04), PLR and lactate (R = −0.294, p = 0.02), MLR and CRP (R = −0.379, p = 0.002), MLR and PCT (R = −0.441, p = 0.001), PLT/MPV and PCT (R = −0.310, p = 0.03), PLT/MPV and lactate (R = −0.443, p = 0.001), PLT/MPV and SAPS II score (R = −0.330, p = 0.01), and PLT/MPV and SOFA score (R = −0.315, p = 0.01). This evidence concerns the gene CRP and septic shock.