Furthermore, comparing all 15 variants between African and European American breast cancer cases, BRCA2 c.2926_2927delinsAT (p.S976I), which was solely detected in African American cases, was the only variant statistically more likely to be observed in either ethnic group (p-value 0.044; Table 4 and S3 Table). This evidence concerns the gene BRCA2 and breast carcinoma.