The previously characterized PAO proteins in clades II (‎Fig 2) including ZmPAO1, HvPAO1, HvPAO2, OsPAO2, OsPAO6 and OsPAO7 have TC catalytic activity while PAOs in clades III, IV, V and VI including BdPAO2,3, AtPAO1~5 and OsPAO1,3~5 are involved in BC pathway. The gene discussed is PAOX; the disease is breast cancer.