These trials have shown the following in chronically infected patients: (a) serum concentrations of vitamins A, E, D and C are decreased [72, 73], (b) vitamins A, D, E and C deficiency is associated with higher levels of viral replication as well as with higher titers of pro-inflammatory cytokines, like IL-6 and TNF-α, or with illness severity in some studies carried out in different virus-associated diseases [72–79], (c) vitamins may suppress or reduce viral replication or load in different virus infections both in adults and in children [80–84]. This evidence concerns the gene TNF and hyperinsulinemic hypoglycemia, familial, 4.